Editorial Perspectives: will SARS-CoV-2 reset public health requirements in the water industry? Integrating lessons of the past and emerging research
A cheery New Year hold lots of happiness for you!给你特别的祝福，愿新年带给你无边的幸福、如意。
Editorial Perspectives: 2019 novel coronavirus (SARS-CoV-2): what is its fate in urban water cycle and how can the water research community respond?
Nano and biosensors for detection of SARS-CoV-2: challenges and opportunities
Soft matter science and the COVID-19 pandemic
The judging committee (of one) has spent weeks deciding which members of the Royal family, politicians and celebrities deserve one of these most galling of gongs to mark a grievous breach of protocol or lapse in mannerly judgement over the past year.
Carbon-based antiviral nanomaterials: graphene, C-dots, and fullerenes. A perspective
Meanwhile, it's onto 2010:
Ultraviolet-C and other methods of decontamination of filtering facepiece N-95 respirators during the COVID-19 pandemic
8. Your appendix might not be a useless evolutionary byproduct after all. Unlike your wisdom teeth, your appendix might actually be serving an important biological function - and one that our species isn't ready to give up just yet.
The more powerful the passions and the more uncontained the ambitions, the more likely the democratic system will collapse into despotism.
The strength of Kellogg/HKUST is the quality of its participants.
Trends and targets in antiviral phototherapy
A new point-of-care test for the diagnosis of infectious diseases based on multiplex lateral flow immunoassays
Novel biosensing methodologies for ultrasensitive detection of viruses
Anti-tumor, -viral, and -bacterial activities of polyoxometalates for realizing an inorganic drug
The 2018 Academic Ranking of World Universities released last Wednesday by Shanghai Ranking Consultancy reveals that 62 research universities in China have made their list of the world's top 500 universities.
The Best Global Universities rankings are based on data and metrics provided by Clarivate Analytics InCites.
ACE2 as a potential therapeutic target for pandemic COVID-19
Diagnostic technologies for COVID-19: a review
7.You Haven't Gotten a Raise in the Last Two Years
Targeting severe acute respiratory syndrome-coronavirus (SARS-CoV-1) with structurally diverse inhibitors: a comprehensive review
The reading represented a fall of 0.4 points from September and a sub-index on output for the gauge, which primarily tracks larger and state-owned enterprises, fell 1.3 points to 53.4. That for new orders dipped 1.9 points to 52.9.
Her mother discovered the debits on Jan 30, China Central Television reported.
An overview of key potential therapeutic strategies for combat in the COVID-19 battle
Potential repurposed SARS-CoV-2 (COVID-19) infection drugs
*最佳综艺节目台本创作：《约翰?奥利佛上周今夜秀》(Last Week Tonight With John Oliver)
Rihanna, who came in at second place, earned her runner-up position "following another 12-month period in which she was absolutely bloody everywhere and yet we all entirely failed to get sick of her," per FHM.
Nature as a treasure trove of potential anti-SARS-CoV drug leads: a structural/mechanistic rationale
The PR industry excelled itself with increasingly fancy descriptions for the basic activities of emailing, talking and meeting. Entrants included: “I want to jump on your radar” (a bad idea, as if you jump on radars they break) and “let’s find a time to connect to mutually update”. My favourite came from a PR man named Michael who wrote: “I hope you don’t mind the outreach.” Alas, I do mind. To reach out has always been hateful, but making it a noun, and reversing the word order, does not help. Michael, you’ve won the Communications cup.
In search for effective and definitive treatment of herpes simplex virus type 1 (HSV-1) infections
Antiviral drug discovery: broad-spectrum drugs from nature
Starbucks, up 49 per cent to 21 in the ranking, has evolved from a café to a place where people can hang out all day since it now sells breakfast, lunch and evening meals, accompanied by alcohol in some places.
The dollar value of exports from emerging market countries will rise next year for the first time since 2014, helped by higher commodity prices and modestly stronger demand, it is predicted.
Influenza neuraminidase: A druggable target for natural products
Frankly, this is unlikely to be ready in time for next year, but we'll include it just in case. The second film from Laszlo Nemes, who won the foreign language Oscar earlier this year for Son of Saul, is a coming-of-age drama set in Budapest just before the first world war.
According to Oliver Cooke, a financial-services recruiter at Selby Jennings in New York, banks have been stressing what they call “internal mobility”, or redeploying staff from one department to another. If a bank facing sluggish conditions in debt trading, for example, can convert a trader to a risk analyst or a compliance officer, it can keep people interested — and it can save a bundle on severance.
From maintenance to flip taxes, condo and co-op owners often complain of boards bleeding them dry. Unfortunately, the cost of running a building will not get any cheaper anytime soon.
Emerging investigators series: the source and fate of pandemic viruses in the urban water cycle
How has your trip to the US sofar this summer?
The role of biosensors in the detection of emerging infectious diseases
Wishing you all the happiness of the holiday season.
Quantitative determination of mechanical stability in the novel coronavirus spike protein
5. You're taking four-hour lunches and have way too many dentist appointments。
Interaction of hydroxychloroquine with SARS-CoV2 functional proteins using all-atoms non-equilibrium alchemical simulations
最近的例子也比比皆是，从乌戈.查韦斯(Hugo Chávez)到欧尔班.维克托(Viktor Orban)和弗拉基米尔.普京(Vladimir Putin)。
对于那些已把自家公寓改造成B&B旅店的纽约人，围绕非法住宿的论战可能会趋于白热化。而在这一切之上，市长比尔·白思豪(Bill de Blasio)的十年保障性住房计划将初具规模；与此同时，本次奥尔巴尼会议(Albany)的立法将给租房者的钱包造成重负。随着我们迈向新的一年，这类改变游戏规则的因素也正在日益迫近。
The spread of HIV through drug injections has been effectively controlled. In 2017, the number of people infected through drug abuse was 44.5 percent lower than that in 2012.
MPLEx: a method for simultaneous pathogen inactivation and extraction of samples for multi-omics profiling
In 2011 the owner of the tomb was identified as Liu Fei (169BC-127BC) the first king of Jiangdu an autonomous kingdom within the Han Dynasty according to China News.
The impact of sluggish growth on year-end payouts may have peaked in 2015, however, when 66 per cent of white-collar workers received no year-end bonus. And the 2016 level actually represents an improvement from 2014, when 61 per cent had to go without.
Multicolored silver nanoparticles for multiplexed disease diagnostics: distinguishing dengue, yellow fever, and Ebola viruses
What dangers does the Fed present to EMs today? One of the biggest risks, says Mr Koepke, is that it might “get behind the curve” and delay raising rates for too long. This would result not only in a surprisingly big hike when it came, but also a higher terminal interest rate than would otherwise be the case.
Inhibition of SARS coronavirus helicase by bismuth complexes
Best chance: If there are nine or 10 best picture nominees, it could grab a spot. Jordan Peele's screenplay looks certain to be recognized.
But the runaway winner was Ford CEO Mark Fields, who began the year with the depressing news that his company was “transitioning from an auto company to an auto company and a mobility company”. He then went on to declare: “Heritage is history with a future.” He was so chuffed with this, he said it more than once. On hearing it repeated, I’ve concluded it is less gnomic than downright moronic. Mr Fields is thus my new Chief Obfuscation Champion.
Unveiling the molecular mechanism of SARS-CoV-2 main protease inhibition from 137 crystal structures using algebraic topology and deep learning
Aoki-san is a pleasure to work withon storyboard. With Aoki-san on the team it feels like a sure thing. The visionof these animations will be perfect.
But nearly two-thirds (65 percent) of white evangelical Protestants say they think the storms are evidence of the "end times" as predicted by the Bible.
A serological aptamer-assisted proximity ligation assay for COVID-19 diagnosis and seeking neutralizing aptamers
In a bid to raise awareness of one of the world's most endangered species and the Chengdu Panda Base in China, the 108 performers were hard to miss as they entertained Londoners and children during school visits with conservationist and base ambassador Nigel Marven.
Average age: 37
Revealing the molecular mechanisms of proteolysis of SARS-CoV-2 Mpro by QM/MM computational methods
The molecular mechanism of the proteolysis reaction catalyzed by SARS-CoV-2 Mpro, one of the enzymes essential for the replication process of the virus responsible for the COVID-19 pandemic, is described using computational QM/MM methods.
Multi-targeting of functional cysteines in multiple conserved SARS-CoV-2 domains by clinically safe Zn-ejectors
By combining evolutionary and physico-chemical principles, previously unknown druggable Zn-sites in multiple conserved SARS-CoV-2 domains have been identified.
Computer-generated “synthetic contingency” plans at times of logistics and supply problems: scenarios for hydroxychloroquine and remdesivir
Engineered unnatural ubiquitin for optimal detection of deubiquitinating enzymes
Mr Ravenscroft believes he would have had a narrower perspective if he had become a management consultant. Teaching also helped him develop a willingness to take risks — the hard way. “If you stand in front of 30 teenagers who won’t hold back when you’re doing something wrong it makes you willing to try things.”
A Digital Protein Microarray for COVID-19 Cytokine Storm Monitoring
Accelerating the repurposing of FDA-approved drugs against coronavirus disease-19 (COVID-19)
A point-of-care selenium nanoparticle-based test for the combined detection of anti-SARS-CoV-2 IgM and IgG in human serum and blood
也许同等重要的是，稳定或者下降的油价将会缓解通货膨胀压力使美国工人的工资更具有购买力。Renaissance Macro经济学家Neil Dutta 称“这对于国内需求来说是一个明确的积极的消息，人们将会有更多可以用来消费的钱”。
Assessing potential inhibitors of SARS-CoV-2 main protease from available drugs using free energy perturbation simulations
The inactivation mechanism of chemical disinfection against SARS-CoV-2: from MD and DFT perspectives
Europe is finally recovering. Japan is also making significant progress. And emerging economies like India, China as well as Indonesia and others, their economic growth rates is likely to be maintained at high levels or likely to accelerate,” he said.
Antiviral agents against COVID-19: structure-based design of specific peptidomimetic inhibitors of SARS-CoV-2 main protease
这款智能产品的使用可以追溯到1800年，但在2016年它才变得“智能”。 Meet Peggy，这种洗衣挂钩能够“帮助你减轻负担”，它会在洗衣机洗好衣服的时候提醒你，并告诉你天气是否适宜晾晒衣服。该装置连接到您的手机，它会在天气变化或是需要转移晾衣服的地方时发消息提醒你。
Pharmacophore-based approaches in the rational repurposing technique for FDA approved drugs targeting SARS-CoV-2 Mpro
Amino acid interacting network in the receptor-binding domain of SARS-CoV-2 spike protein
Greener liquid-phase synthesis and the ACE inhibitory structure–activity relationship of an anti-SARS octapeptide
Upon downloading WeChat, users are prompted to register either using their QQ accounts or their cell phone numbers. The application then helps users populate their contact lists using existing entries in their cell phone address books. To communicate, users can upload any photo or video on their device, take new ones, or press a button to save a voice message that is transferred almost instantaneously. Voice messages are played back with short beeps at the end to imitate the feeling of instant connection, similar to a two-way radio.
Anti-inflammatory, antiallergic and COVID-19 protease inhibitory activities of phytochemicals from the Jordanian hawksbeard: identification, structure–activity relationships, molecular modeling and impact on its folk medicinal uses
The biomaterial polyphosphate blocks stoichiometric binding of the SARS-CoV-2 S-protein to the cellular ACE2 receptor
Ilimaquinone (marine sponge metabolite) as a novel inhibitor of SARS-CoV-2 key target proteins in comparison with suggested COVID-19 drugs: designing, docking and molecular dynamics simulation study
*Guest Actress in a Drama Series: Margo Martindale, “The Americans”
Design and optimization of a subunit vaccine targeting COVID-19 molecular shreds using an immunoinformatics framework
幸好这类单曲只是《名誉》这张专辑的一部分。在《Dress》（《连衣裙》）这首歌中，她沉醉于令人激动的新恋情里；在《New Year’s Day》（《新年》）这首歌中，她试着弄明白聚会结束后她还拥有什么。
Several coumarin derivatives and their Pd(II) complexes as potential inhibitors of the main protease of SARS-CoV-2, an in silico approach
Coumarin derivatives and their Pd(II)-complexes have shown a higher binding potential towards SARS-CoV-2 Mpro than chloroquine/cinanserin along with lower toxicity.
Carotane sesquiterpenes from Ferula vesceritensis: in silico analysis as SARS-CoV-2 binding inhibitors
Sesquiterpenes, 8α-anisate-dauc-4-ene-3,9-dione (webiol anisate) (1) and 10α-acetoxy-6α-benzoate-jaeschkeanadiol (2) as well as several analogues (3–12) were root extracted from Ferula vesceritensis.
Quinazoline-Schiff base conjugates: in silico study and ADMET predictions as multi-target inhibitors of coronavirus (SARS-CoV-2) proteins
Design of 2-phenylquinazolin-4(3H)one-trihydroxyphenyl Schiff base conjugates as COVID-19 therapy.
Automated multiplex nucleic acid tests for rapid detection of SARS-CoV-2, influenza A and B infection with direct reverse-transcription quantitative PCR (dirRT-qPCR) assay in a centrifugal microfluidic platform
With the prices of most commodities having recovered somewhat since February 2016, the year-on-year fall in unit prices has slowed to around 5 per cent.
Ten years ago, Steele was a successful investment advisor speaking at ITU World, a United Nations conference on technology for government. That same week, California experienced its first-ever gubernatorial election recall. Steele couldn't believe these kinds of hiccups were happening during such important races (the infamous Florida presidential election recall was only three years prior), so she decided to solve the problem herself. To date,169 countries, including Bosnia-Herzegovina, used Everyone Counts' electronic voting platform, as did the Academy Awards committee.
A modular microarray imaging system for highly specific COVID-19 antibody testing
Development of a tablet PC-based portable device for colorimetric determination of assays including COVID-19 and other pathogenic microorganisms
Australia is the No. 8 Best Country overall. The Land Down Under – No. 4 in Quality of Life and No. 9 in Adventure – also ranks in the top 10 in terms of education.
In the near future, a weary Logan (Hugh Jackman) cares for an ailing Professor X (Patrick Stewart) at a remote outpost on the Mexican border. His plan to hide from the outside world gets upended when he meets a young mutant (Dafne Keen) who is very much like him. Logan must now protect the girl and battle the dark forces that want to capture her.
Inhibition of SARS-CoV-2 main protease by phenolic compounds from Manilkara hexandra (Roxb.) Dubard assisted by metabolite profiling and in silico virtual screening
4. Will China's one-child policy change in 2010?
Rapid prediction of possible inhibitors for SARS-CoV-2 main protease using docking and FPL simulations
A combination of Autodock Vina and FPL calculations suggested that periandrin V, penimocycline, cis-p-Coumaroylcorosolic acid, glycyrrhizin, and uralsaponin B are able to bind well to SARS-CoV-2 Mpro.
Curcumin to inhibit binding of spike glycoprotein to ACE2 receptors: computational modelling, simulations, and ADMET studies to explore curcuminoids against novel SARS-CoV-2 targets
This whole week was a train wreck: the unconvincing denials, the timing of the Cousins trade on All-Star Sunday, the pathetic return value,
The regulator said that “faced with a complex and volatile market environment,” funds had realised gains of only Rmb294.5bn in the first half, a drop of 42.3 per cent.
A density functional theory study on silver and bis-silver complexes with lighter tetrylene: are silver and bis-silver carbenes candidates for SARS-CoV-2 inhibition? Insight from molecular docking simulation
An in silico perception for newly isolated flavonoids from peach fruit as privileged avenue for a countermeasure outbreak of COVID-19
3′-Hydroxy-4′-methoxy-chroman-7-O-β-D-glucopyranoside 4, together with three known compounds, ferulic acid heptyl ester 1, naringenin 2, and 4,2′,4′-trihydroxy-6′-methoxychalcone-4′-O-β-D-glucopyranoside 3, was isolated from peach fruits.
Understanding the role of galectin inhibitors as potential candidates for SARS-CoV-2 spike protein: in silico studies
14) When socializing, I don't find the right things to talk about 0 1 2 3 4
Characterization of a commercially-available, low-pressure UV lamp as a disinfection system for decontamination of common nosocomial pathogens on N95 filtering facepiece respirator (FFR) material
8. Jessica Gomes
Helsinki-based developer Remedy Entertainment has blurred the line between Hollywood and games with previous incarnations Max Payne and Alan Wake. Now the studio is combining next-generation visuals with the tension and drama of scripted television. Set in the university town of Riverport, Quantum Break puts players in control of Jack Joyce and Beth Wilder, a pair of ordinary people who are given the extraordinary power to manipulate time after an accident that creates a time rift. Time will randomly break down during the game, which causes disasters in the environment that pause, stutter, rewind and freeze. Fans of Max Payne’s bullet time will see new strategies emerge with gunfights involving time-amplified combat as the player fights against the Monarch Corporation. In addition to the virtual storyline, the game features custom live action storytelling that’s personalized based on the decisions one makes.
A facile assay for rapid detection of COVID-19 antibodies
5. Mother Nature
Potential role of medicinal plants and their constituents in the mitigation of SARS-CoV-2: identifying related therapeutic targets using network pharmacology and molecular docking analyses
With his technical genius and startup launched, he's not planning on going back and finishing high school, either."This is my third time applying for the Fellowship. I first applied when I was 14," he said. "I told my parents when I first applied and they weren’t really supportive. But then they kind of saw what I was doing in high school, I wasn’t spending my time as effectively as I could. I started spending more of my time at MIT and they understood. When I did receive the fellowship, they were supportive."Fortunately for Sohmers, he's in good hands. He's part of class No. 3 and Thiel fellows have a promising track record so far: it's launched 67 companies that have created 135 full-time jobs and raised $55.4 million in angel and venture funding, the Wall Street Journal's Lora Kolodny reports.At 17, Sohmers is unconcerned that being a high-school dropout will affect his career in any way."If I don’t end up changing the world with this I can find something else," he said. "People think that there’s a big thought war between these two sides [education versus entrepreneurship]. But when it comes to the researchers, they care less about the degrees that you have, and more about what you can actually do."
Thirty-six Chinese brands have made it onto the list this year. Among them, eight are in the top 100, including the State Grid Corporation of China (36), the Industrial and Commercial Bank of China (ICBC) (40), Tencent (43), China Central Television (CCTV) (62), Haier (76), China Mobile (79), Huawei (81) and Lenovo (90).
She was also recognised for being the youngest recipient of the Ripple of Hope Award from the Robert F. Kennedy Center for her charity work.
Remdesivir-bound and ligand-free simulations reveal the probable mechanism of inhibiting the RNA dependent RNA polymerase of severe acute respiratory syndrome coronavirus 2
Consensus virtual screening of dark chemical matter and food chemicals uncover potential inhibitors of SARS-CoV-2 main protease
For the fifth year in a row the city-state's Changi Airport has been named "world's best airport" at the annual Skytrax World Airport Awards.
Sectors: what’s in
Clinical decision support tool and rapid point-of-care platform for determining disease severity in patients with COVID-19
Justin Bieber剃发募捐 集得4万美金
Whole-genome sequence analysis and homology modelling of the main protease and non-structural protein 3 of SARS-CoV-2 reveal an aza-peptide and a lead inhibitor with possible antiviral properties
DeMarcus Cousins, Serge Ibaka and Lou Williams were all dealt in advance of Thursday's 3 p.m. ET deadline, leaving role players like Taj Gibson and P.J. Tucker as the biggest names to move right before the buzzer.
Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease
Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease.
Smartphone-based multiplex 30-minute nucleic acid test of live virus from nasal swab extract
The Producer Price Index (PPI), which gauges factory-gate prices and is a major indicator of economic briskness, rose by 6.3% in 2017, compared with a minus 1.4% for 2016, reversing the trend of continual decline since 2012.
Anti-HIV drug repurposing against SARS-CoV-2
Consumer Electronics Show
You'd love to know the balance of forces that shape and move your ponytail, right? That's why Joseph Keller, Raymond Goldstein, Patrick Warren and Robin Ball received this igNOMINIOUS prize!
Length-scale dependence of protein hydration-shell density
Since 1983 the annual Spring Festival Gala hosted by China Central Television has always been an important part of the Chinese Lunar New Year celebration - no wonder every move organizers make becomes the center of attention.
Trade flows brought China’s balance of trade to $40.82bn, roughly $7.2bn below expectations and down about $3.6bn from November’s revised level of $44.23bn (previously $44.61bn). That balance came to Rmb275.4bn in local-currency terms.
The June announcement of collaboration between Google and fashion designer Diane von Furstenberg to create a new line of Google Glass underscored Silicon Valley’s current strategy to enlist the fashion elite to sanction wearables as de rigueur.
Stand: Costco CEO Craig Jelinek refused to open on Thanksgiving Day
High antiviral activity of mercaptoethane sulfonate functionalized Te/BSA nanostars against arterivirus and coronavirus
John Stevenage, chief executive of British Mensa, said he was delighted for Nishi. He said: 'I hope she will make full use of her membership to meet new, like-minded people and challenge herself. Joining Mensa opens the door to an international network of more than 100,000 people and many members make friends for life.
A handheld continuous-flow real-time fluorescence qPCR system with a PVC microreactor
Will the Federal Reserve's path out of bond buying get bumpy?
日前，斯坦福大学商学院(Stanford Graduate School of Business)教授彼得o库迪斯基于这场荷兰危机共同撰写了一篇文章，围绕“个人经验（而非市场信息）决定乐观、悲观以及信贷的获得与否”这种不那么科学的方法给出了现代经验。
In dollar terms, imports plunged 18.8 per cent last month to $114.19, from a 7.6 per cent drop in January and versus an expected drop of 3.6 per cent.
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As if 2016 hadn’t been hard enough for China’s workforce, an annual survey has revealed that more than half of the country’s white-collar employees got no year-end bonus ahead of the upcoming (and costly) lunar new year holiday.