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Themed collection Coronavirus articles - free to access collection

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Editorial

Editorial Perspectives: will SARS-CoV-2 reset public health requirements in the water industry? Integrating lessons of the past and emerging research

国际货币基金组织(IMF)总裁克里斯蒂娜?拉加德(Christine Lagarde)表示,她除了今年的全球经济复苏(recovery)充满期待外,还对另外两个“R”感到担忧。第一个是“风险”(risk),她认为,一些旧有的风险(例如完成金融业改革的必要性)与美国缩减定量宽松政策的相关风险一样重要,此外还有针对欧元区可能陷入通缩等问题所新产生的担忧。
Set over one summer, the film follows precocious 6-year-old Moonee as she courts mischief and adventure with her ragtag playmates and bonds with her rebellious but caring mother, all while living in the shadows of Disney World.

Graphical abstract: Editorial Perspectives: will SARS-CoV-2 reset public health requirements in the water industry? Integrating lessons of the past and emerging research
Editorial

Editorial Perspectives: 2019 novel coronavirus (SARS-CoV-2): what is its fate in urban water cycle and how can the water research community respond?

n. 奇思妙想,一段楼
I get that Frank Vogel is experimenting to find a winning rotation, but this roster is so unbalanced and the best prospects aren't being put in great positions.

Graphical abstract: Editorial Perspectives: 2019 novel coronavirus (SARS-CoV-2): what is its fate in urban water cycle and how can the water research community respond?
From the themed collection: 乡村振兴对城市居民是重要利好
Open Access Accepted Manuscript - Highlight

Nano and biosensors for detection of SARS-CoV-2: challenges and opportunities

Open Access Perspective

Soft matter science and the COVID-19 pandemic

Sweden

Graphical abstract: Soft matter science and the COVID-19 pandemic
From the themed collection: 建筑钢材市场或将延续弱势
Open Access Perspective

Carbon-based antiviral nanomaterials: graphene, C-dots, and fullerenes. A perspective

East New York in Brooklyn will be the test case when the Department of City Planning presents initial recommendations early next year. After that, the rezoning process could begin for the neighborhood, among the city’s poorest. A proposal for west Flushing in Queens is next.

Graphical abstract: Carbon-based antiviral nanomaterials: graphene, C-dots, and fullerenes. A perspective
Perspective

Ultraviolet-C and other methods of decontamination of filtering facepiece N-95 respirators during the COVID-19 pandemic

One of the men even swoops in to give the girl a quick kiss on the cheek. He turns around in mock-embarrassment and gives his friend a hug, while the young woman speaks to her friend in French.
1. Battle of the Sexes
7. Political wars guarantee intense volatility through 2014-2016 elections
多达10000份影片(一个虚构CIA刺杀北韩领袖金正恩的喜剧片)和500000份宣传单将会在3月26号左右通过气球投放。

Graphical abstract: Ultraviolet-C and other methods of decontamination of filtering facepiece N-95 respirators during the COVID-19 pandemic
Perspective

Trends and targets in antiviral phototherapy

达洛伊西奥常喜欢说“时间是新的货币”。这是一个17岁男孩对人生的睿智洞察,也是Summly软件背后的发展理念。而我们多数人在他那个年龄,时间多得都不知道该怎么做才不会荒废。我很容易就忘了这样一个事实:达洛伊西奥在1995年出生于一个中上层阶级家庭,连高中都还没毕业,还住在小时候住的那个舒服卧室里。在我和他父母聊天的时候,他离开房间去在电脑上干活。只见他穿着袜子下楼,牛仔裤腿扫过大厅的地毯──此时此刻是他最像个孩子的时候。
For parents, it is always a struggle to carry their children all day long, especially when they’re getting bigger and heavier.
Enrollment: 503
extravagant

Graphical abstract: Trends and targets in antiviral phototherapy
Minireview

A new point-of-care test for the diagnosis of infectious diseases based on multiplex lateral flow immunoassays

位居榜单第三的是史蒂夫·卡瑞尔(Steve Carell)。《卑鄙的我2》(Despicable Me 2)在今年大获成功,斩获票房9.19亿美元。该电影系列累计已取得14亿美元的全球票房,该系列第三部《小黄人》(Minions)也即将上映。卡瑞尔今年还出演了小制作独立影片《迷途知返》(The Way Way Back)和《超级魔术师》(The Incredible Burt Wonderstone)。后一部影片的票房虽未能赚回制作成本,但是我们这里只关注票房收入——该部影片为卡瑞尔2013年的电影票房收入又添2,250万美元。

Graphical abstract: A new point-of-care test for the diagnosis of infectious diseases based on multiplex lateral flow immunoassays
Minireview

Novel biosensing methodologies for ultrasensitive detection of viruses

改编自上世纪70年代真实贿赂事件的影片《美国骗局》当晚表现更加抢眼,埃米?亚当斯(Amy Adams)和珍妮弗?劳伦斯(Jennifer Lawrence)凭此片分获最佳女主角和最佳女配角奖。《为奴十二年》虽在提名数量上与《美国骗局》打平,参与了七个奖项的角逐,但当晚只摘得最佳剧情片一个奖项。

Graphical abstract: Novel biosensing methodologies for ultrasensitive detection of viruses
Application

Anti-tumor, -viral, and -bacterial activities of polyoxometalates for realizing an inorganic drug

Thank you,
Ahh, the glamorous life of AT&T: best friends with Steve Jobs, exclusive rights to the iPhone (for now) and carrier of choice on the iPad. So why, with everything going for it, did the stock miss a huge rally? In the year ending April 1, Apple soared 109% and the S&P 500 rose 41%. AT&T? Down 2%. The problem is growth, or lack thereof: little in its saturated wireless business and a decline in landlines, which still accounts for 25% of sales. Unless its high-speed Internet business takes off or the iPad drives new wireless growth, the beatings by Wall Street will continue.

Graphical abstract: Anti-tumor, -viral, and -bacterial activities of polyoxometalates for realizing an inorganic drug
Open Access Review Article

ACE2 as a potential therapeutic target for pandemic COVID-19

格里芬高中时代的样子与现今相差无几,原因是他离开高中才四年。我们能想象得出,暴力美学的格里芬在NBA里再锻炼上一两年年,他会变得更“怪兽”。
The 54-episode series The Journey of Flower was one of the hottest topics on social media. The TV drama became a hit in the summer of 2015. The movie starring Huo Jianhua and Zhao Liying is based on a novel of the same title written by Fresh Guoguo. The aesthetical adaptation has picturesque outdoor scene in a Chinese ink painting style and charming male and female lead roles, attracting 800,000 followers on the drama`s official Weibo. The drama premiered in June of 2015. It tells a story from a female perspective of an orphan`s growth and romance on her way to becoming a goddess.

Graphical abstract: ACE2 as a potential therapeutic target for pandemic COVID-19
Open Access Review Article

Diagnostic technologies for COVID-19: a review

不过,在这一反弹中也出现了奖金数额的下滑:去年的平均年终奖是12821元人民币(合1861美元),比2015年多了大约2000元人民币,却仍比2014年的平均值少了800元人民币。在奖金缩水的被调查者中,逾四分之一的人将原因归结为公司业绩太差。
The Asia-Pacific is the common home of all countries in the region. China does not want to see any party in the Asia-Pacific region feel compelled to choose sides under the influence of a Cold-War mentality.

Graphical abstract: Diagnostic technologies for COVID-19: a review
Open Access Review Article

Targeting severe acute respiratory syndrome-coronavirus (SARS-CoV-1) with structurally diverse inhibitors: a comprehensive review

'It's going to get volatile to the upside,' he said.
1. Bubble With No Name Yet triggers the biggest crash in 30 years
昨日,108名表演者身着熊猫服装,穿行在伦敦的街头,向大众宣传这种惹人喜爱却面临灭绝危险的黑白物种。
Gunmen kidnapped 18 Turkish workers Wednesday in Iraq's capital.

Graphical abstract: Targeting severe acute respiratory syndrome-coronavirus (SARS-CoV-1) with structurally diverse inhibitors: a comprehensive review
Open Access Review Article

An overview of key potential therapeutic strategies for combat in the COVID-19 battle

清华大学和北京大学分别排在第14位和第17位,与它们去年各自的排名相同。

Graphical abstract: An overview of key potential therapeutic strategies for combat in the COVID-19 battle
Open Access Review Article

Potential repurposed SARS-CoV-2 (COVID-19) infection drugs

British schools outperform the French on both new criteria. Warwick Business School, the top UK school for career progress, is second overall for the criterion, 30 places above the first French school, HEC Paris. Alumni from UK schools also see a higher increase between their first salary after graduation and now, at 62 per cent versus 45 per cent. However, UK school alumni still have a lower salary on average than their counterparts who studied in France, at $55,000 versus $64,000.
Welcome, and before we begin – please accept our apologies. Your four-hour nightmare wait at passport control should not be taken as a symptom of Britain's contempt for foreigners. It is merely a symptom of a woeful lack of spending on a key aspect of travel infrastructure in the run-up to a hugely important event. In other words, it's the government that hates you. Don't worry, they hate us too.

Graphical abstract: Potential repurposed SARS-CoV-2 (COVID-19) infection drugs
Open Access Review Article

Nature as a treasure trove of potential anti-SARS-CoV drug leads: a structural/mechanistic rationale

美国的排放量一直在降低,这是因为发电过程中燃烧天然气的比例增加了;与煤炭相比,燃气发电每单位能量所产生的二氧化碳更少。但美国通报称,2013年的排放量有所增加,因为煤炭重新获得了一些市场份额。如果这种趋势持续下去,它可能会成为奥巴马政府的一个挑战,因为奥巴马政府正试图制定更严格的温室气体政策。

Graphical abstract: Nature as a treasure trove of potential anti-SARS-CoV drug leads: a structural/mechanistic rationale
Review Article

In search for effective and definitive treatment of herpes simplex virus type 1 (HSV-1) infections

“我试图做到的是继承他的衣钵,写一本典型的伊恩·弗莱明式的007小说。”

Graphical abstract: In search for effective and definitive treatment of herpes simplex virus type 1 (HSV-1) infections
Review Article

Antiviral drug discovery: broad-spectrum drugs from nature

'I think South Korea has a very rigorous and narrow definition of beauty because we’re an ethnically homogenous society and everyone looks pretty much the same. It is also related to low self-esteem.
The two gunmen who slaughtered 12 people at satirical newspaper Charlie Hebdo,Cherif Kouachi and his brother Said, were likely among those who had left the country to "to be trained to kill and to sow terror".
McDonald's (MCD, Fortune 500), the all-American fast food Mecca, announced it would put $20 billion towards share repurchases and dividends Thursday, jumping on board the buyback trend that has boomed over the past 18 months.
n. 运输、运输工具;(常用复数)强烈的情绪(狂喜或狂怒

Graphical abstract: Antiviral drug discovery: broad-spectrum drugs from nature
Review Article

Influenza neuraminidase: A druggable target for natural products

2.“老爹身材”受热捧
汉达·阿亚里谴责激进的伊斯兰教,制造了一场风暴。现在,在#我也是 运动的鼓舞下,她指控牛津大学的一位教授强奸她。
Accepting the award, he enthused: 'First off, I want to start off by saying that I'm not really sure how I got this because I've had my album out a few years, but I've got one coming,' before thanking his fans and MTV. Elsewhere, Kendrick Lamar was presented with Best Video, though the rapper was unable to attend the event, instead thanking fans via a video link.
In the past five years, China's exports of goods grew at an annual average of 6.5 percent, with its share in the global market rising form 10.4 percent in 2010 to about 13.2 percent in 2015, faring much better than major global economies. Service trade grew over 13.6 percent each year, marking the world's second largest service trader.
James is proof of a trend we've seen, from Tim Duncan to Manu Ginobili to Vince Carter. Conditioning, health science and nutrition are paving the way for athletes to remain in their prime, and then serviceable, for way longer than before. James is realistically still going to be the best player on his team when he's 36, and that's straight up bonkers.

Graphical abstract: Influenza neuraminidase: A druggable target for natural products
Critical Review

Emerging investigators series: the source and fate of pandemic viruses in the urban water cycle

这位微软公司创始人的净资产是860亿美元,而一年前则是750亿美元。
阿方索?卡隆(Alfonso Cuaron)凭藉广受好评的全球热门太空科幻影片《地心引力》(Gravity)赢得最佳导演奖。《地心引力》、《美国骗局》和《为奴十二年》均有可能成为今年奥斯卡奖(Academy Awards)的夺奖热门,本周四将公布今年奥斯卡奖提名名单。(与金球奖不同,奥斯卡奖还设置技术类奖项。)

Graphical abstract: Emerging investigators series: the source and fate of pandemic viruses in the urban water cycle
Critical Review

The role of biosensors in the detection of emerging infectious diseases

虽然原著的豆瓣评分有7.9,但电视剧却因为劣质的改编仅获得5分。

Graphical abstract: The role of biosensors in the detection of emerging infectious diseases
Communication

Quantitative determination of mechanical stability in the novel coronavirus spike protein

我们的前路应有尽有,我们的前路一无所有……

Graphical abstract: Quantitative determination of mechanical stability in the novel coronavirus spike protein
Communication

Interaction of hydroxychloroquine with SARS-CoV2 functional proteins using all-atoms non-equilibrium alchemical simulations

现在压力都在诺埃尔这里了,他得证明自己远比在76人时期迷失在混乱中的时候强。
According to the list, ge (哥, older brother, big brother) is without doubt the hottest net word of the year. Both of the top two cited lines use the word. In Chinese, ge here is used more like the first person pronoun (like the English, “Can a brother get a break?”)
会。美国政府在垂直合并案上已有数十年没赢过。据美国司法部(Department of Justice)自己的审查指导原则,像时代华纳这样的内容所有者与AT&T这样的分销商之间的“垂直合并”,远不如水平合并那么令人担忧。与此同时,Facebook、亚马逊(Amazon)、Netflix和谷歌(Google)这四巨头(合称FANG,取每家名称首字母)如今主宰了数字娱乐版图,这使得政府的如下论点更难以站住脚:两家传统媒体公司的合并,会从根本上改变竞争态势。
伊朗持不同政见电影人扮演一个几乎不合格的德黑兰出租车司机,带来一部狡猾的伪纪录片,深入探讨电影的悖论,以及专制统治下日常生活中的矛盾。

Graphical abstract: Interaction of hydroxychloroquine with SARS-CoV2 functional proteins using all-atoms non-equilibrium alchemical simulations
Communication

MPLEx: a method for simultaneous pathogen inactivation and extraction of samples for multi-omics profiling

1.take hard classes
网络红人前10名的微博粉丝数加起来超过了4000万。其中最著名的Papi酱签署的视频广告价值竟然达到了令人震惊的2200万元。
e出,pi,sode与sell的过去试sold发音一样:出门把pi卖了,这绝对是人生的一个插曲。
?Bond has a keen eye for who to trust and who not to. This quality is frequently seen in sexually open-minded people, actually. 007 can tell when a lady is into him. And science agrees: handsome men are the best at identifying who is attracted to them.

Graphical abstract: MPLEx: a method for simultaneous pathogen inactivation and extraction of samples for multi-omics profiling
Communication

Multicolored silver nanoparticles for multiplexed disease diagnostics: distinguishing dengue, yellow fever, and Ebola viruses

However, the economists polled expect slightly higher growth rates and substantially higher inflation over 2016.
它轻便易折叠,适合携带出行。

Graphical abstract: Multicolored silver nanoparticles for multiplexed disease diagnostics: distinguishing dengue, yellow fever, and Ebola viruses
From the themed collection: O2O将会是板材行业的翻身机会吗?
Communication

Inhibition of SARS coronavirus helicase by bismuth complexes

[k?n'tinju?s]
If you constantly arrive late to work, or return late from breaks, it displays an attitude of complacency and carelessness. So be prompt or even a bit early to show that you are time conscious and that you do care about your job and other people’s time, as well.
Hope you enjoy the happiness of New Year and all the trimmings.
12月份以美元计的进口同比增长3.1%至1686亿美元,而上个月修正后的增幅为4.7%(修正前为6.7%)。这一增长幅度大致符合3%预期中数。
办事处副局长卢华东说:“自治区已投资40亿元人民币(约合6亿美元),用于推动贫困地区特色的产业,去年重新安置了77000名贫困人口。”

Graphical abstract: Inhibition of SARS coronavirus helicase by bismuth complexes
Open Access Edge Article

Unveiling the molecular mechanism of SARS-CoV-2 main protease inhibition from 137 crystal structures using algebraic topology and deep learning

肠道细菌正以我们想像不到的方式干扰着我们。新的研究指出,像帕金森综合症等神经退行性疾病实际上可能始于肠道,而不是大脑。越来越多的证据显示,慢性疲劳综合征可能要归咎于人体内的微生物群系。随着肠道细菌显示出控制食欲以及改变大脑结构的迹象,而且有引起大脑损伤而导致中风的表现,我们的这个小过客(肠道细菌)有着不容忽视的力量。
Bernard Baumohl, chief global economist of the Economic Outlook Group, said he is even more optimistic. "The next two years could be the best two we have seen in at least a decade," he said. "There is clearly a lot of evidence the economy is gaining a lot of momentum."
“只要总体市场仍然相对积极,只要交易继续执行良好,我们继续预期今年余下时间会保持健康的交易量,”高盛(Goldman Sachs)美洲股票资本市场主管戴维?路德维格(David Ludwig)表示。

Graphical abstract: Unveiling the molecular mechanism of SARS-CoV-2 main protease inhibition from 137 crystal structures using algebraic topology and deep learning
Open Access Edge Article

A serological aptamer-assisted proximity ligation assay for COVID-19 diagnosis and seeking neutralizing aptamers

立场:呼吁结束政府停摆局面
谷歌的品牌价值现在超过了1090亿美元,比苹果公司要高大约20亿美元,这使其成为了全世界最赚钱的公司。

Graphical abstract: A serological aptamer-assisted proximity ligation assay for COVID-19 diagnosis and seeking neutralizing aptamers
Open Access Edge Article

Revealing the molecular mechanisms of proteolysis of SARS-CoV-2 Mpro by QM/MM computational methods

The molecular mechanism of the proteolysis reaction catalyzed by SARS-CoV-2 Mpro, one of the enzymes essential for the replication process of the virus responsible for the COVID-19 pandemic, is described using computational QM/MM methods.

Graphical abstract: Revealing the molecular mechanisms of proteolysis of SARS-CoV-2 Mpro by QM/MM computational methods
Open Access Edge Article

Multi-targeting of functional cysteines in multiple conserved SARS-CoV-2 domains by clinically safe Zn-ejectors

By combining evolutionary and physico-chemical principles, previously unknown druggable Zn-sites in multiple conserved SARS-CoV-2 domains have been identified.

Graphical abstract: Multi-targeting of functional cysteines in multiple conserved SARS-CoV-2 domains by clinically safe Zn-ejectors
Open Access Edge Article

Computer-generated “synthetic contingency” plans at times of logistics and supply problems: scenarios for hydroxychloroquine and remdesivir

7.The Renminbi's Devaluation
总部位于纽约的世界品牌实验室编纂并于上周一发布了《2016世界品牌500强》榜单,苹果公司夺得了第一名的宝座。
编者案:伦敦奥运会开幕在即,让我们来看看本届奥运会都有哪些比赛项目吧,同时在看看的同时也不要忘了学学比赛项目的词汇,一举两得何乐而不为呢?

Graphical abstract: Computer-generated “synthetic contingency” plans at times of logistics and supply problems: scenarios for hydroxychloroquine and remdesivir
Open Access Edge Article

Engineered unnatural ubiquitin for optimal detection of deubiquitinating enzymes

在世界五大电脑制造商中,苹果公司是去年唯一一家出货量保持增长的公司,涨幅超过了6%;宏碁公司则是下跌幅度最大,下跌超过了18%。
There are few chief executive decisions that drew more attention this year than Yahoo(YHOO, Fortune 500) CEO Marissa Mayer's work-from-home ban. The policy was initially seen as highly controversial and had a lot of people upset because of its perceived lack of flexibility.
Theresa May is still facing resistance from within her own party. Vince Cable, the Liberal Democrats’ sage and leader, still thinks Brexit may not really happen.

Graphical abstract: Engineered unnatural ubiquitin for optimal detection of deubiquitinating enzymes
Accepted Manuscript - Paper

A Digital Protein Microarray for COVID-19 Cytokine Storm Monitoring

Open Access Paper

Accelerating the repurposing of FDA-approved drugs against coronavirus disease-19 (COVID-19)

But some people might just remember the mustaches.

Graphical abstract: Accelerating the repurposing of FDA-approved drugs against coronavirus disease-19 (COVID-19)
From the themed collection: 门窗行业五大消费行情解析
Paper

A point-of-care selenium nanoparticle-based test for the combined detection of anti-SARS-CoV-2 IgM and IgG in human serum and blood

You might think Hawaiian has it relatively easy, since its flights rarely have to contend with the kind of challenging weather conditions found on the mainland. Hawaiian perennially rates high in on-time performance rankings, topping the most recent DOT list i n September. It recently announced it will branch well beyond its island home with non-stop service to Beijing.

Graphical abstract: A point-of-care selenium nanoparticle-based test for the combined detection of anti-SARS-CoV-2 IgM and IgG in human serum and blood
From the themed collection: 家居体验馆引领家装新潮流
Open Access Paper

Assessing potential inhibitors of SARS-CoV-2 main protease from available drugs using free energy perturbation simulations

sur下面+rog要求…要求做下去…代理+ate表名词,“人或地位”→代理人,代替品
你倾向于隐藏自己的感情吗?

Graphical abstract: Assessing potential inhibitors of SARS-CoV-2 main protease from available drugs using free energy perturbation simulations
From the themed collection: 养老服务:住得上 更要住得好
Open Access Paper

The inactivation mechanism of chemical disinfection against SARS-CoV-2: from MD and DFT perspectives

We will perform with a strong work ethic, sense of responsibility, and enterprising spirit.
Phil Baty, editor of THE rankings, said: "China has introduced powerful policy drives, backed with serious funding, to produce world-class universities. In 2015, the country announced its excellence initiative, which aims to establish six of its universities in the leading group of global institutions by 2020."
在毕业3年后的学员当中,男女毕业生薪资分别为9万美元和7.3万美元,相差近22%。刚完成学业时的男女毕业生薪资差距为17%,因此男女薪资差距随着时间推移而扩大(见图表)。
Coca-Cola cut its sales forecast for this year as it struggles with a consumer slowdown in China, sending the drinks group’s shares down more than 3 per cent.

Graphical abstract: The inactivation mechanism of chemical disinfection against SARS-CoV-2: from MD and DFT perspectives
From the themed collection: 儿童家具召回难谁之过?
Open Access Paper

Antiviral agents against COVID-19: structure-based design of specific peptidomimetic inhibitors of SARS-CoV-2 main protease

These are the official James Bond theme songs, ranked from worst to best, with two honorable mentions because they may or may not count, but were just that good, dang it.
还是得作秀

Graphical abstract: Antiviral agents against COVID-19: structure-based design of specific peptidomimetic inhibitors of SARS-CoV-2 main protease
Open Access Paper

Pharmacophore-based approaches in the rational repurposing technique for FDA approved drugs targeting SARS-CoV-2 Mpro

(G.I. Joe: Retaliation)以及两部小规模电影,加起来在全球的票房收入总计13亿美元。
Qualcomm

Graphical abstract: Pharmacophore-based approaches in the rational repurposing technique for FDA approved drugs targeting SARS-CoV-2 Mpro
From the themed collection: 北京市开始试水“租购同权”
Open Access Paper

Amino acid interacting network in the receptor-binding domain of SARS-CoV-2 spike protein

《人物》评选的电影史上35位美人(1)

Graphical abstract: Amino acid interacting network in the receptor-binding domain of SARS-CoV-2 spike protein
Paper

Greener liquid-phase synthesis and the ACE inhibitory structure–activity relationship of an anti-SARS octapeptide

The book reflects growing anxiety in some quarters about the possible negative impact of automation on jobs, from manufacturing to professional services. The subtitle of its UK edition warns of “the threat of mass unemployment” and, in the US edition, foresees “a jobless future”.
China's online retail volume is expected to outperform the rest of the world by reaching four trillion yuan (618 billion USdollars) this year, Commerce Minister Gao Hucheng said Sunday.
['?unip]
在屏幕前对女主人公大喊“不要在深夜独自下楼”,不再是徒劳无用的了。在这款互动式惊悚游戏中,玩家可以控制游戏人物的行动。游戏的剧情由电影制片人拉里o法森顿和格拉哈姆o雷兹尼克与游戏开发商Supermassive Games精心打造。故事中,八位好友被困在遥远的山区度假村,还有一名不受限制的精神病人。游戏群星云集,其中包含《神盾局特工》(Agents of S.H.I.E.L.D)的演员布雷特o道顿,美剧《纳什维尔》(Nashville)的演员海顿o潘妮蒂尔和《极品飞车》(Need for Speed)的演员拉米o马雷克。玩家将控制各个角色探索这个恐怖的世界,试图在黎明到来时存活下来。没有人是安全的。在游戏中,每一个决定都会导致不同的结果。游戏剧本长达一千余页,拥有数百个不同结局等待玩家发掘。蝴蝶效应使得游戏不会有相同的剧情,而唯一不变的是,这款游戏十分惊悚。不要独自一人或是在深夜里尝试它。

Graphical abstract: Greener liquid-phase synthesis and the ACE inhibitory structure–activity relationship of an anti-SARS octapeptide
Open Access Paper

Anti-inflammatory, antiallergic and COVID-19 protease inhibitory activities of phytochemicals from the Jordanian hawksbeard: identification, structure–activity relationships, molecular modeling and impact on its folk medicinal uses

While oil prices may rebound in 2015, they almost certainly won't return to $100 a barrel any time soon, barring a geopolitical crisis in a major petroleum-producing region. So the gift will keep giving this year and further feed an accelerating U.S. recovery.
最佳迷你剧集/电影类编剧:D?V?蒂文森斯(D.V. DeVincentis),《美国罪案故事:公诉辛普森》,“玛西亚,玛西亚,玛西亚” (The People v. O. J. Simpson: American Crime Story, "Marcia, Marcia, Marcia")

Graphical abstract: Anti-inflammatory, antiallergic and COVID-19 protease inhibitory activities of phytochemicals from the Jordanian hawksbeard: identification, structure–activity relationships, molecular modeling and impact on its folk medicinal uses
Open Access Paper

The biomaterial polyphosphate blocks stoichiometric binding of the SARS-CoV-2 S-protein to the cellular ACE2 receptor

随着我国对稳定经济的新驱动力的投资增加,2016年我国的科技研究与试验发展经费达1.57万亿元,增长10.6%,是2014年以来最快的年增速。
单词conservative 联想记忆:
New Year comes but once a year. But when it comes it brings good cheer.新年一年只有一次,但每次来临都带来喜悦。

Graphical abstract: The biomaterial polyphosphate blocks stoichiometric binding of the SARS-CoV-2 S-protein to the cellular ACE2 receptor
Open Access Paper

Ilimaquinone (marine sponge metabolite) as a novel inhibitor of SARS-CoV-2 key target proteins in comparison with suggested COVID-19 drugs: designing, docking and molecular dynamics simulation study

但他并没有做到这些。所以普莱斯蒂聪明的在他还有交易价值的时候把他送走了。
要让Airbnb退市,可能没那么容易。最近,昆尼皮亚克大学(Quinnipiac)开展的一项民意调查表明,56%的受访者认为,应该允许纽约人将房间租给陌生人。“我们不想把房子变成旅馆,但是与此同时,人们有时会想把自己的公寓租出去。”霍尔斯特德管理公司(Halstead Management Company)的总裁保罗·R·戈特塞根(Paul R. Gottsegen)说。该公司打理着纽约市250处住宅物业。
200911/88512.shtmlDuring NATO’s 1999 air war over Yugoslavia the Atlantic alliance struck hundreds of targets over Serbia and Kosovo. Most were uncontroversial: air-defense sites army headquarters and other military targets. The destruction of one target in particular however set off a wave of anti-Western—and anti-American in particular—protests half a world away. That target was the Chinese embassy in Belgrade.

Graphical abstract: Ilimaquinone (marine sponge metabolite) as a novel inhibitor of SARS-CoV-2 key target proteins in comparison with suggested COVID-19 drugs: designing, docking and molecular dynamics simulation study
Open Access Paper

Design and optimization of a subunit vaccine targeting COVID-19 molecular shreds using an immunoinformatics framework

9. The 2012 Ig Nobel Anatomy Prize
Microscopic as the subjects are, the benefits of the scientists’ research are set to be huge.

Graphical abstract: Design and optimization of a subunit vaccine targeting COVID-19 molecular shreds using an immunoinformatics framework
Open Access Paper

Several coumarin derivatives and their Pd(II) complexes as potential inhibitors of the main protease of SARS-CoV-2, an in silico approach

Coumarin derivatives and their Pd(II)-complexes have shown a higher binding potential towards SARS-CoV-2 Mpro than chloroquine/cinanserin along with lower toxicity.

Graphical abstract: Several coumarin derivatives and their Pd(ii) complexes as potential inhibitors of the main protease of SARS-CoV-2, an in silico approach
Open Access Paper

Carotane sesquiterpenes from Ferula vesceritensis: in silico analysis as SARS-CoV-2 binding inhibitors

Sesquiterpenes, 8α-anisate-dauc-4-ene-3,9-dione (webiol anisate) (1) and 10α-acetoxy-6α-benzoate-jaeschkeanadiol (2) as well as several analogues (3–12) were root extracted from Ferula vesceritensis.

Graphical abstract: Carotane sesquiterpenes from Ferula vesceritensis: in silico analysis as SARS-CoV-2 binding inhibitors
Open Access Paper

Quinazoline-Schiff base conjugates: in silico study and ADMET predictions as multi-target inhibitors of coronavirus (SARS-CoV-2) proteins

Design of 2-phenylquinazolin-4(3H)one-trihydroxyphenyl Schiff base conjugates as COVID-19 therapy.

Graphical abstract: Quinazoline-Schiff base conjugates: in silico study and ADMET predictions as multi-target inhibitors of coronavirus (SARS-CoV-2) proteins
Open Access Paper

Automated multiplex nucleic acid tests for rapid detection of SARS-CoV-2, influenza A and B infection with direct reverse-transcription quantitative PCR (dirRT-qPCR) assay in a centrifugal microfluidic platform

I, however, am not among them.
It has now entered the top 20 for the first time.
By the end of 2015, Shanghai's population of migrant residents had decreased to 9.8 million, comprising 40.6 percent of the city's roughly 24 million permanent residents, according to statistics released by the Shanghai Municipal Statistics Bureau on Monday.

Graphical abstract: Automated multiplex nucleic acid tests for rapid detection of SARS-CoV-2, influenza A and B infection with direct reverse-transcription quantitative PCR (dirRT-qPCR) assay in a centrifugal microfluidic platform
Open Access Paper

A modular microarray imaging system for highly specific COVID-19 antibody testing

Here's a look into social media's crystal ball for 2014. Will Snapchat catch fire? Will those annoying Promoted Tweets keep invading your Twitter stream? Will your boss finally learn to tweet? These five trends are poised to shake up the industry and the way we use social media in 2014:
Ellen DeGeneres:

Graphical abstract: A modular microarray imaging system for highly specific COVID-19 antibody testing
Open Access Paper

Development of a tablet PC-based portable device for colorimetric determination of assays including COVID-19 and other pathogenic microorganisms

女性地位继续上升。
Additional reporting from Stefan Wagstyl in Berlin
眼下,合格的供应链经理极度缺乏,在那些分支机构遍布全球的跨国公司中尤其如此。究其原因,不外以下两点。

Graphical abstract: Development of a tablet PC-based portable device for colorimetric determination of assays including COVID-19 and other pathogenic microorganisms
Open Access Paper

Inhibition of SARS-CoV-2 main protease by phenolic compounds from Manilkara hexandra (Roxb.) Dubard assisted by metabolite profiling and in silico virtual screening

斯托特说,对于2015年破纪录的气温来说,当前的厄尔尼诺现象可能只负有10%的责任。厄尔尼诺现象令太平洋海水变暖,是自然界一种经常性现象。

Graphical abstract: Inhibition of SARS-CoV-2 main protease by phenolic compounds from Manilkara hexandra (Roxb.) Dubard assisted by metabolite profiling and in silico virtual screening
Open Access Paper

Rapid prediction of possible inhibitors for SARS-CoV-2 main protease using docking and FPL simulations

A combination of Autodock Vina and FPL calculations suggested that periandrin V, penimocycline, cis-p-Coumaroylcorosolic acid, glycyrrhizin, and uralsaponin B are able to bind well to SARS-CoV-2 Mpro.

Graphical abstract: Rapid prediction of possible inhibitors for SARS-CoV-2 main protease using docking and FPL simulations
Open Access Paper

Curcumin to inhibit binding of spike glycoprotein to ACE2 receptors: computational modelling, simulations, and ADMET studies to explore curcuminoids against novel SARS-CoV-2 targets

法国电信商学院(Télécom Business School)和布拉格经济大学(University of Economics)的教师性别比例最为均衡,女教师占50%,瑞士苏黎世大学(University of Zurich)的教师性别比例最不均衡,女教师仅为9%。瑞士洛桑国际管理发展学院(IMD)的教师队伍国际化程度最高,94%来自海外,米兰理工大学MIP管理学院的教师则均为意大利人。
Bedrooms are up a curving staircase. A loft-like library overlooks the central atrium. Walls of glass in the master suite and its en-suite bathroom take in acres of marshland. The suite opens to a sun deck on the water side of the house. Both other bedrooms also have en-suite bathrooms. The lower level is finished as a gym, with a half bath and a garage with space for several cars.

Graphical abstract: Curcumin to inhibit binding of spike glycoprotein to ACE2 receptors: computational modelling, simulations, and ADMET studies to explore curcuminoids against novel SARS-CoV-2 targets
Open Access Paper

A density functional theory study on silver and bis-silver complexes with lighter tetrylene: are silver and bis-silver carbenes candidates for SARS-CoV-2 inhibition? Insight from molecular docking simulation

单词original 联想记忆:
3. Poverty

Graphical abstract: A density functional theory study on silver and bis-silver complexes with lighter tetrylene: are silver and bis-silver carbenes candidates for SARS-CoV-2 inhibition? Insight from molecular docking simulation
Open Access Paper

An in silico perception for newly isolated flavonoids from peach fruit as privileged avenue for a countermeasure outbreak of COVID-19

3′-Hydroxy-4′-methoxy-chroman-7-O-β-D-glucopyranoside 4, together with three known compounds, ferulic acid heptyl ester 1, naringenin 2, and 4,2′,4′-trihydroxy-6′-methoxychalcone-4′-O-β-D-glucopyranoside 3, was isolated from peach fruits.

Graphical abstract: An in silico perception for newly isolated flavonoids from peach fruit as privileged avenue for a countermeasure outbreak of COVID-19
From the themed collection: 小区物管要谁干 业主一户一票选
Open Access Paper

Understanding the role of galectin inhibitors as potential candidates for SARS-CoV-2 spike protein: in silico studies

“In the drama, romance is the protagonist’s only pursuit. It seems that the meaning of her life is to have a romantic relationship with a Prince Charming. No, not only one, but three or four,” Douban user Jiuyuehuashang said.
《一记耳光》(The Slap),NBC,2月12日播出。乔恩·罗宾·贝茨(Jon Robin Baitz)与丽莎·查罗登科(Lisa Cholodenko)担任制作人,这部剧改编自一部澳大利亚迷你剧,讲述一个后院生日派对失控后带来的后果。演员阵容非常强大,包括彼得·萨斯加德(Peter Sarsgaard)、乌玛·瑟曼(Uma Thurman)、桑迪·牛顿(Thandie Newton)、布莱恩·考克斯(Brian Cox)和梅丽莎·乔治(Melissa George,她也在原剧中出演角色)。

Graphical abstract: Understanding the role of galectin inhibitors as potential candidates for SARS-CoV-2 spike protein: in silico studies
Paper

Characterization of a commercially-available, low-pressure UV lamp as a disinfection system for decontamination of common nosocomial pathogens on N95 filtering facepiece respirator (FFR) material

专业一点
Zhang's piece is “so lush and so rich and so full and so complete,” Google Doodle team leader Ryan Germick told the Washington Post. “Every leaf seemed to have life in it.”

Graphical abstract: Characterization of a commercially-available, low-pressure UV lamp as a disinfection system for decontamination of common nosocomial pathogens on N95 filtering facepiece respirator (FFR) material
Open Access Paper

A facile assay for rapid detection of COVID-19 antibodies

['stresf?l]

Graphical abstract: A facile assay for rapid detection of COVID-19 antibodies
Open Access Paper

Potential role of medicinal plants and their constituents in the mitigation of SARS-CoV-2: identifying related therapeutic targets using network pharmacology and molecular docking analyses

Inflation (and deflation) won't rear its ugly head Surging oil production — along with slower global growth — has caused the price of petroleum to collapse from more than $100 a barrel last summer to barely $50 a barrel at the end of 2014. The effect has been to reverse an uptick in U.S. inflation earlier in the year.
We will promote coordinated urban development above and below the ground, and begin construction on at least another 2,000 kilometers of underground utility tunnels in cities. A three-year initiative will be launched to remove the risk of flooding in highly vulnerable urban areas; and further progress will be made in the development of sponge cities. All these efforts will make our cities more attractive and function better.
但经济学家总体上预计,一旦飓风造成的失真消失,前段时间的趋势就有望恢复并延续。接受《华尔街日报》最新月度调查的45位经济学家预计,到明年6月,失业率将降至7.8%,2013年年底将降至7.5%。部分经济学家说,就业增长可能会摆脱现在的缓慢速度而加快。信安环球投资有限公司(Principal Global Investors)经济学家鲍尔(Bob Baur)说,我觉得到时候企业将必须招人。[qh]
The Caixin-sponsored series is based on a much smaller sample of private companies than the official PMI reading, which focuses on larger state enterprises, and tends to be more volatile.

Graphical abstract: Potential role of medicinal plants and their constituents in the mitigation of SARS-CoV-2: identifying related therapeutic targets using network pharmacology and molecular docking analyses
Open Access Paper

Remdesivir-bound and ligand-free simulations reveal the probable mechanism of inhibiting the RNA dependent RNA polymerase of severe acute respiratory syndrome coronavirus 2

Movie buffs will soon be able to celebrate with a visual feast at the Beijing International Film Festival, where nearly 500 high quality films will be shown.

Graphical abstract: Remdesivir-bound and ligand-free simulations reveal the probable mechanism of inhibiting the RNA dependent RNA polymerase of severe acute respiratory syndrome coronavirus 2
Open Access Paper

Consensus virtual screening of dark chemical matter and food chemicals uncover potential inhibitors of SARS-CoV-2 main protease

The upshot: The world's largest economy can still function as an oasis in a desert despite the claims of doomsayers that those days are over.
谢丽尔·布恩·艾萨克斯,学院理事会主席
WHAT: A Greek Revival with four bedrooms and four and a half bathrooms

Graphical abstract: Consensus virtual screening of dark chemical matter and food chemicals uncover potential inhibitors of SARS-CoV-2 main protease
From the themed collection: 家具建材市场频现“联盟促销”
Open Access Paper

Clinical decision support tool and rapid point-of-care platform for determining disease severity in patients with COVID-19

我们首先得明白我们所有人都不知道这次选秀会怎么发展,毕竟大学联赛还在进行。但当所有的这些新鲜的血液都齐聚乐透区,这看起来当然美如画。
traditional

Graphical abstract: Clinical decision support tool and rapid point-of-care platform for determining disease severity in patients with COVID-19
Paper

Whole-genome sequence analysis and homology modelling of the main protease and non-structural protein 3 of SARS-CoV-2 reveal an aza-peptide and a lead inhibitor with possible antiviral properties

It was therapeutic for Warriors fans after enduring the agony of the worst collapse in Finals history the year before, but even then, the whole thing felt like "yup, this is what's supposed to happen." There was very little drama, very little debate, and in the end, the result everyone was sure of happened. That doesn't generate a lot of conversation or interest. It just kind of is what it is.
“This has been a miserable year for EM,” said Paul McNamara, investment director of emerging markets at GAM, the Swiss fund house. “There has been a steady bleed out of assets and no one is certain what shape the market might be in this time next week.”

Graphical abstract: Whole-genome sequence analysis and homology modelling of the main protease and non-structural protein 3 of SARS-CoV-2 reveal an aza-peptide and a lead inhibitor with possible antiviral properties
Open Access Paper

Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease

Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease.

Graphical abstract: Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease
Paper

Smartphone-based multiplex 30-minute nucleic acid test of live virus from nasal swab extract

上海实施新措施一年以来,受理外籍人士及其家属永久居留申请同比增长6倍。

Graphical abstract: Smartphone-based multiplex 30-minute nucleic acid test of live virus from nasal swab extract
Open Access Paper

Anti-HIV drug repurposing against SARS-CoV-2

4.《欲望都市》掀起纸杯蛋糕热
They appeared in high spirits despite losing three-nil to Belgium on Saturday .
crew

Graphical abstract: Anti-HIV drug repurposing against SARS-CoV-2
Paper

Length-scale dependence of protein hydration-shell density

n. 家仆,
米拉?库妮丝排名第二,其后是凯特?阿普顿、流行歌星蕾哈娜和艾玛?斯通。
蕾哈娜在榜单上排名第二,获得亚军,《男人装》表示:在这12个月以来,她真是无处不在,但是我们依然没有对她审美疲劳。
The story of the strong V-shaped recovery of the Chinese economy this year was followed by reports of soaring housing prices in many cities.

Graphical abstract: Length-scale dependence of protein hydration-shell density
Open Access Paper

High antiviral activity of mercaptoethane sulfonate functionalized Te/BSA nanostars against arterivirus and coronavirus

5)我支持你:我们都犯过大错误。此时,不要回避,要对对方说一些肯定的话语:“我不是在说你不行。你会度过这个难关的。你不是一个人在战斗。我们将一起解决此事。一切都会没事的。”
23% of wealthy Chinese women work in real estate and 18% of them are involved in finance and investment, followed by manufacturing accounting for 14%.

Graphical abstract: High antiviral activity of mercaptoethane sulfonate functionalized Te/BSA nanostars against arterivirus and coronavirus
Paper

A handheld continuous-flow real-time fluorescence qPCR system with a PVC microreactor

大宗农产品投机交易一直是今年市场波动的一个特点,荷兰合作银行预测,这种趋势将继续。
n. 克制,控制,管制,操作装置
时间:2010-03-31 编辑:vicki

Graphical abstract: A handheld continuous-flow real-time fluorescence qPCR system with a PVC microreactor
From the themed collection: 行业颠覆元年家居市场涌现新变化
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高效老板和经理们趋向于:
We will advance reforms in the financial sector.

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